The COVID-19 situation in Italy is much, much improved however several restrictions are still in place which would make a September 2021 trip difficult and quite less enjoyable than in the past. 

For everyone’s information this is the page we frequently visit for up to date on Covid-19 information for tourists:
Covid-19 updates: information for tourists – Info (italia.it)

Trip is Tentative for 2022 with final decision before 4/1/2022.